Warty dyskeratoma wd is a benign epidermal proliferation first reported in 1957 because of its distinctive histologic findings. Warty dyskeratoma wd of the right lower eyelid in a 60yearold woman presenting as a slowly growing papule. Wd presents as an umbilicated papule with a keratotic plug, usually limited to the head, neck, or face. It was called warty dyskeratoma by szymanski in 1957. The pathogenesis remains uncertain, but uv light, autoimmunity, and smoking may play a role. The cause of warty dyskeratoma is unknown, and hence, currently there are no known methods to prevent the tumor occurrence.
Warty dyskeratomafocal acantholytic dyskeratosisan update. However, azuma has reported a case of multiple warty dyskeratomas of the scalp, neck, cheeks and hands, similar to the two cases we present, and he suggests a follicular origin for the lesions, as clinically they arc follicularly based, and upon histological examination, early lesions are associated with sebaceous glands. Isolated lesions with histologic features almost indistinguishable from those in darier disease were first given special standing by helwig. It usually appears as a solitary reddishbrown papule, but cases of multiple lesions have been observed. Additional and relevant useful information for warty dyskeratoma. The profound dyskeratotic changes may mimic invasive squamous cell carcinoma.
Histologic examination showed the lesion to be a warty dyskeratoma. Wd presents as a whitish or grayish solitary papule or as a small nodule with a keratotic plug, usually limited to the head and neck of middleaged patients. Plaque form of warty dyskeratoma acantholytic dyskeratotic acanthoma. Pdf warty dyskeratoma is a rare tumor that presents mainly as an isolated papule or nodule on the scalp, face or neck in the adults. Pdf warty dyskeratoma is a benign dermatose that is characterized by a soliter papule or a nodule. Ko, md key facts clinical issues solitary very rarely multiple umbilicated papule or nodule often on head or neck microscopic pathology cupshaped lesion sometimes associated with hair follicles hyperkeratosis and parakeratosis suprabasilar acantholysis with villi at base mixed inflammatory infiltrate in dermis.
White homogeneous area with 3 yellow clods with intervening hair follicles arrows. Pdf dermoscopy of multiple warty dyskeratomas semantic. Graham and helwig first described warty dyskeratoma as isolated dariers disease in 1954. Warty dyskeratoma wd is a benign solitary lesion of unknown aetiology affecting the skin and oral mucosa. Warty dyskeratoma journal of the american academy of dermatology. It usually presents as a solitary, asymptomatic umbilicated papule, most often in the head and neck region of middle to olderage adults. Plaque form of warty dyskeratoma acantholytic dyskeratotic. Phelps and others published warty dyskeratoma of the eyelid find, read and cite all the research you need on researchgate. Warty dyskeratoma wd, also known as isolated darier disease or focal acantholytic dyskeratosis,1 is a rare mucocutaneous lesion. Wd presents as a whitish or grayish solitary papule or small nodules with a keratotic plug, usually limited to the head and neck of middleaged patients.
Case of warty dyskeratoma with unique dermoscopic features. Because it often arises in association with a dilated hair follicle, it has been postulated to have a follicular origin. Clinical findings are similar to verruca vulgaris, irritated seboreik. Until now, these changes have been described only on the skin and the mucosa of the oral cavity. Warty dyskeratoma may represent an abnormal keratinization response to intraoral trauma or inflammation. Jan 23, 2017 warty dyskeratoma wd is a benign epidermal proliferation first reported in 1957 because of its distinctive histologic findings.
Introduction warty dyskeratoma wd is an unusual benign tumour with a follicular origin. According to some authors, majority of these lesions display overall histopathologic features consistent with a follicular adnexal neoplasm. Warty dyskeratoma wd, also known as isolated follicular dyskeratosis, is relatively uncommon benign epidermal proliferation first reported by szymanski in 19571. Warty dyskeratoma is a benign dermatose that is characterized by a soliter papule or a nodule. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment.
Histologically similar lesions have been described in the oral region mainly by case reports and under the terms wd or focal acantholytic dyskeratosis fad. View large image view hires image download powerpoint slide. Dyskeratoma definition of dyskeratoma by medical dictionary. Pdf warty dyskeratoma wd is a rare epidermal tumor that frequently arises as a papule or nodule on the head or. Jan 06, 2019 the cause of warty dyskeratoma is unknown, and hence, currently there are no known methods to prevent the tumor occurrence. A patient with warty dyskeratoma was successfully treated with tazarotenic acid gel.
The histopathology shows a pattern of acantholytic dyskeratosis. Acantholytic dyskeratosis an overview sciencedirect topics. To our knowledge, our case includes the first description of this lesion on the vocal cord. Oral warty dyskeratoma jama dermatology jama network. Warty dyskeratoma is a solitary lesion of unknown etiology that has microscopic resemblence to dariers disease.
Warty dyskeratoma involving two adjoining follicles. An elderly woman had a small verrucose hyperkeratotic papule on the hard palate. Lesions are generally solitary but grouped verrucous papules on the scalp. Warty dyskeratoma is an uncommon entity characterized by a solitary keratotic papule or nodule usually located in the head and neck of young adults. Warty dyskeratoma, also known as localized darier disease, is a very uncommon lesion that can develop on either the skin or oral mucosa.
We report a 32yearold man who presented pain, serous exudation, a distal onycholysis with subungual hyperkeratosis, and roundish erythronychia in the nail plate of his left first. The cause is unknown, although the microscopic features are very similar to those of darier disease. Warty dyskeratoma, also known as localized darier disease, is a very uncommon lesion that can develop on either the skin or oral. Pdf dermoscopy of multiple warty dyskeratomas researchgate.
A small number of cases have been reported in the oral mucosa, usually overlying the alveolar ridge or the palate. Manual dermoscopy revealed a pale, homogeneous area mottled by 3 brown to yellow marbled clods adjacent to several. Widespread keratosis follicularis is an entity that has been familiar to dermatologists since it was described by darier in 1889. A high proportion of the rare genital, crural, and perineal cases referred to as papular acantholytic dyskeratosis see above have had a histological resemblance to haileyhailey disease, with prominent acantholysis and little or no dyskeratosis. Warty dyskeratoma frequently arises as a single lesion with a central keratotic plug on the skin of middleaged or elderly people. We present evidence to support that this did not occur by chance and suggest that tazarotenic acid be investigated further for the treatment of similar dyskeratatic disorders. Warty dyskeratomafocal acantholytic dyskeratosis an update on a rare oral lesion irit allon department of oral pathology and oral medicine, school of dental medicine, tel. Warty dyskeratoma is a tiny, nodular lesion with a characteristic histologic picture that resembles that of dariers disease. We present an unusual location of warty dyskeratoma in the nail bed using a clinicohistopathological correlation for the diagnosis. Warty dyskeratoma, also known as an isolated dyskeratosis follicularis.
Warty dyskeratoma wd is an uncommon lesion of the skin that is considered to be associated with the pilosebaceous apparatus. Histologically, it shows a cupshaped keratinfilled invagination of an acanthotic epidermis, suprabasilar. Dermoscopy of multiple warty dyskeratomas dermatology. Warty dyskeratoma wd is regarded as a benign follicular adnexal neoplasm. We herein report a multiple warty dyskeratoma in a female patient. The relationship between its dermoscopic and histopathological findings. Warty dyskeratomafocal acantholytic dyskeratosis an update. Warty dyskeratoma wd is a rare epidermal tumor that frequently arises as a papule or nodule on the head or neck of middleaged or older persons.
Multiple warty dyskeratomas are a rare occurrence and their. Warty dyskeratoma of the leg jama dermatology jama network. Warty dyskeratoma of the oral mucosa british journal of oral and. While warty dyskeratoma of the oral mucosa is rare, it appears to exhibit a. Pdf warty dyskeratoma involving two adjoining follicles. A note concerning its occurrence on the oral mucosa. Multiple warty dyskeratomas are very rare cutaneous lesions which are mostly seen on the scalp.
Suprabasal acantholysis of the epidermis is a histopathologic common denominator of diverse conditions such as pemphigus vulgaris, benign familial pemphigus haileyhailey, transient acantholytic dermatosis grovers disease, some actinic keratoses and cutaneous squamous carcinomas. Warty dyskeratoma isolated dyskeratosis follicularis is generally thought of as a cutaneous lesion of the head and neck regions. Clinical findings are similar to verruca vulgaris, irritated seboreik keratoses and hypertrophic actinic keratoses. Trichilemmomas are benign follicular neoplasms that exhibit differentiation toward the outer root sheath of the pilosebaceous follicular epithelium. Treatment of warty dyskeratoma with tazarotenic acid. View enhanced pdf access article on wiley online library html view download pdf for offline viewing. Warty dyskeratoma definition of warty dyskeratoma by. Skin warty dyskeratoma, or follicular dyskeratoma, is a relatively uncommon, benign, follicular adnexal neoplasm that usually appears between the 5th and 7th decades of life and is most prevalent in white men. Warty dyskeratoma wd, also known as isolated follicular dyskeratosis, is a relatively uncommon benign epidermal proliferation first reported by szymanski in 1957. An unusual location of subungual warty dyskeratoma. When it occurs in the oral cavity, wd is most commonly seen on the hard palate. Treatment of warty dyskeratoma with tazarotenic acid sciencedirect. Of these 112 cases, 88 were located on the head or neck, 17 on the trunk, three on the extremities upper, one on the buccal mucosa, and three in unknown areas.
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